Research ArticleArticle
Small Molecule Inhibitors of ERCC1-XPF Protein-Protein Interaction Synergize Alkylating Agents in Cancer Cells
Lars Petter Jordheim, Khaled H. Barakat, Laurence Heinrich-Balard, Eva-Laure Matera, Emeline Cros-Perrial, Karima Bouledrak, Rana El Sabeh, Rolando Perez-Pineiro, David S. Wishart, Richard Cohen, Jack Tuszynski and Charles Dumontet
Molecular Pharmacology July 2013, 84 (1) 12-24; DOI: https://doi.org/10.1124/mol.112.082347
Lars Petter Jordheim
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Khaled H. Barakat
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Laurence Heinrich-Balard
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Eva-Laure Matera
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Emeline Cros-Perrial
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Karima Bouledrak
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Rana El Sabeh
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Rolando Perez-Pineiro
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
David S. Wishart
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Richard Cohen
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Jack Tuszynski
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
Charles Dumontet
Université de Lyon (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), Université Lyon 1 (L.P.J., L.H.-B., E.-L.M., E.C.-P., K.B., R.E.S., R.C., C.D.), INSERM U1052, Centre de Recherche en Cancérologie de Lyon (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.), and CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France (L.P.J., E.-L.M., E.C.-P., K.B., R.E.S., C.D.); Department of Physics, University of Alberta, Edmonton, Alberta, Canada (K.H.B., J.T.); Department of Engineering Mathematics and Physics, Fayoum University, Fayoum, Egypt (K.H.B.); MATEIS UMR-CNRS 5510, ISPB Faculté de Pharmacie, Lyon, France (L.H.-B., R.C.); Department of Biological Sciences (R.P.-P., D.S.W.) and Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada (R.P.-P., D.S.W.); Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et de Biologie Moléculaire, Lyon Cedex 03, France (R.C.); and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada (J.T.)
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Research ArticleArticle
Inhibitors of ERCC1-XPF Interaction
Lars Petter Jordheim, Khaled H. Barakat, Laurence Heinrich-Balard, Eva-Laure Matera, Emeline Cros-Perrial, Karima Bouledrak, Rana El Sabeh, Rolando Perez-Pineiro, David S. Wishart, Richard Cohen, Jack Tuszynski and Charles Dumontet
Molecular Pharmacology July 1, 2013, 84 (1) 12-24; DOI: https://doi.org/10.1124/mol.112.082347
Research ArticleArticle
Inhibitors of ERCC1-XPF Interaction
Lars Petter Jordheim, Khaled H. Barakat, Laurence Heinrich-Balard, Eva-Laure Matera, Emeline Cros-Perrial, Karima Bouledrak, Rana El Sabeh, Rolando Perez-Pineiro, David S. Wishart, Richard Cohen, Jack Tuszynski and Charles Dumontet
Molecular Pharmacology July 1, 2013, 84 (1) 12-24; DOI: https://doi.org/10.1124/mol.112.082347
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