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Research ArticleArticle

Functional Validation of Virtual Screening for Novel Agents with General Anesthetic Action at Ligand-Gated Ion Channels

Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692
Stephanie A. Heusser
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Rebecca J. Howard
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Cecilia M. Borghese
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Madeline A. Cullins
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Torben Broemstrup
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Ui S. Lee
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Erik Lindahl
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Jens Carlsson
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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R. Adron Harris
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Article Information

vol. 84 no. 5 670-678
DOI 
https://doi.org/10.1124/mol.113.087692
PubMed 
23950219

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 5, 2013
  • Accepted August 15, 2013
  • Published online October 7, 2013.

Article Versions

  • Earlier version (August 15, 2013 - 07:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephanie A. Heusser,
  2. Rebecca J. Howard1,
  3. Cecilia M. Borghese,
  4. Madeline A. Cullins,
  5. Torben Broemstrup,
  6. Ui S. Lee,
  7. Erik Lindahl,
  8. Jens Carlsson, and
  9. R. Adron Harris
  1. Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
  1. Address correspondence to:
    R. Adron Harris, University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Cellular and Molecular Biology, 2500 Speedway, Stop A4800, Austin, TX 78712-1639. E-mail address: harris{at}austin.utexas.edu
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Molecular Pharmacology: 84 (5)
Molecular Pharmacology
Vol. 84, Issue 5
1 Nov 2013
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Research ArticleArticle

Validation of Virtual Screening for Anesthetics in LGICs

Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 1, 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692

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Research ArticleArticle

Validation of Virtual Screening for Anesthetics in LGICs

Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 1, 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692
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