Research ArticleArticle
The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism
Brian D. Hudson, Bharat Shimpukade, Amanda E. Mackenzie, Adrian J. Butcher, John D. Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B. Tobin, Trond Ulven and Graeme Milligan
Molecular Pharmacology November 2013, 84 (5) 710-725; DOI: https://doi.org/10.1124/mol.113.087783
Brian D. Hudson
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Bharat Shimpukade
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Amanda E. Mackenzie
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Adrian J. Butcher
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
John D. Pediani
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Elisabeth Christiansen
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Helen Heathcote
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Andrew B. Tobin
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Trond Ulven
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
Graeme Milligan
Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (B.D.H., A.E.M., J.D.P., H.H., G.M.); Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense, Denmark (B.S., E.C., T.U.); and MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom (A.J.B., A.B.T.)
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Research ArticleArticle
The Therapeutic Potential of FFA4
Brian D. Hudson, Bharat Shimpukade, Amanda E. Mackenzie, Adrian J. Butcher, John D. Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B. Tobin, Trond Ulven and Graeme Milligan
Molecular Pharmacology November 1, 2013, 84 (5) 710-725; DOI: https://doi.org/10.1124/mol.113.087783
Research ArticleArticle
The Therapeutic Potential of FFA4
Brian D. Hudson, Bharat Shimpukade, Amanda E. Mackenzie, Adrian J. Butcher, John D. Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B. Tobin, Trond Ulven and Graeme Milligan
Molecular Pharmacology November 1, 2013, 84 (5) 710-725; DOI: https://doi.org/10.1124/mol.113.087783
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