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Rapid CommunicationMinireview

Molecular Responses to Hypoxia-Inducible Factor 1α and Beyond

Jason Brocato, Yana Chervona and Max Costa
Molecular Pharmacology May 2014, 85 (5) 651-657; DOI: https://doi.org/10.1124/mol.113.089623
Jason Brocato
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York
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Yana Chervona
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York
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Max Costa
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York
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Abstract

Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1α and HIF-2α proteins and is regulated by a number of cellular pathways involving both oxygen-dependent and -independent mechanisms. Stabilization of HIF-1α activates transcription of genes that participate in key pathways in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion. Since its discovery more than two decades ago, HIF-1α has become a hot topic in molecular research and has been implicated not only in disease pathology but also in prognosis. In this review, we will focus on recent insights into HIF-1α regulation, function, and gene expression. We will also discuss emerging data on the involvement of HIF in cancer prognosis and therapeutic interventions.

Footnotes

    • Received September 12, 2013.
    • Accepted February 25, 2014.
  • This work was supported by the National Institutes of Health National Institute of Environmental Health Sciences [Grants P30-ES000260, P42-ES010344, R01-ES014454, and R01-ES005512].

  • dx.doi.org/10.1124/mol.113.089623.

  • Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 85 (5)
Molecular Pharmacology
Vol. 85, Issue 5
1 May 2014
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Rapid CommunicationMinireview

Molecular Responses to HIF-1α and Beyond

Jason Brocato, Yana Chervona and Max Costa
Molecular Pharmacology May 1, 2014, 85 (5) 651-657; DOI: https://doi.org/10.1124/mol.113.089623

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Rapid CommunicationMinireview

Molecular Responses to HIF-1α and Beyond

Jason Brocato, Yana Chervona and Max Costa
Molecular Pharmacology May 1, 2014, 85 (5) 651-657; DOI: https://doi.org/10.1124/mol.113.089623
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  • Article
    • Abstract
    • Introduction
    • Oxygen-Dependent Regulation of HIF Signaling
    • Oxygen-Independent Regulation of HIF Signaling
    • HIF-1α and Gene Expression
    • HIF-1α and Jumonji Domain–Containing Histone Demethylases
    • HIF-1α and Cancer Prognosis
    • HIF-1α and Therapeutic Interventions
    • Conclusion
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