Research ArticleArticle
Direct Activation of β-Cell KATP Channels with a Novel Xanthine Derivative
Rene Raphemot, Daniel R. Swale, Prasanna K. Dadi, David A. Jacobson, Paige Cooper, Andrew P. Wojtovich, Sreedatta Banerjee, Colin G. Nichols and Jerod S. Denton
Molecular Pharmacology June 2014, 85 (6) 858-865; DOI: https://doi.org/10.1124/mol.114.091884
Rene Raphemot
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Daniel R. Swale
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Prasanna K. Dadi
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
David A. Jacobson
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Paige Cooper
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Andrew P. Wojtovich
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Sreedatta Banerjee
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Colin G. Nichols
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
Jerod S. Denton
Departments of Anesthesiology (R.R., D.R.S., S.B., J.S.D.), Pharmacology (R.R., J.S.D.), and Molecular Physiology and Biophysics (P.K.D., D.A.J.) and Institutes of Chemical Biology (J.S.D.) and Global Health (J.S.D.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Rochester Medical Center, Rochester, New York (A.P.W.); and Department of Cell Biology and Physiology (P.C., C.G.N.) and Center for the Investigation of Membrane Excitability Disorders (P.C., C.G.N.), Washington University School of Medicine in St. Louis, St. Louis, Missouri
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Discovery of a Xanthine-Based Kir6.2/SUR1 Activator
Rene Raphemot, Daniel R. Swale, Prasanna K. Dadi, David A. Jacobson, Paige Cooper, Andrew P. Wojtovich, Sreedatta Banerjee, Colin G. Nichols and Jerod S. Denton
Molecular Pharmacology June 1, 2014, 85 (6) 858-865; DOI: https://doi.org/10.1124/mol.114.091884
Research ArticleArticle
Discovery of a Xanthine-Based Kir6.2/SUR1 Activator
Rene Raphemot, Daniel R. Swale, Prasanna K. Dadi, David A. Jacobson, Paige Cooper, Andrew P. Wojtovich, Sreedatta Banerjee, Colin G. Nichols and Jerod S. Denton
Molecular Pharmacology June 1, 2014, 85 (6) 858-865; DOI: https://doi.org/10.1124/mol.114.091884
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