Research ArticleArticle
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro
Mei-Chuan Chen, Bingsen Zhou, Keqiang Zhang, Yate-Ching Yuan, Frank Un, Shuya Hu, Chih-Ming Chou, Chun-Han Chen, Jun Wu, Yan Wang, Xiyong Liu, D. Lynne Smith, Hongzhi Li, Zheng Liu, Charles D. Warden, Leila Su, Linda H. Malkas, Young Min Chung, Mickey C.-T. Hu and Yun Yen
Molecular Pharmacology June 2015, 87 (6) 996-1005; DOI: https://doi.org/10.1124/mol.114.094987
Mei-Chuan Chen
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Bingsen Zhou
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Keqiang Zhang
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Yate-Ching Yuan
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Frank Un
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Shuya Hu
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Chih-Ming Chou
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Chun-Han Chen
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Jun Wu
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Yan Wang
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Xiyong Liu
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
D. Lynne Smith
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Hongzhi Li
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Zheng Liu
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Charles D. Warden
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Leila Su
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Linda H. Malkas
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Young Min Chung
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Mickey C.-T. Hu
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
Yun Yen
Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan
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Research ArticleArticle
RNR Inhibitor COH29 Interferes with DNA Repair Pathways
Mei-Chuan Chen, Bingsen Zhou, Keqiang Zhang, Yate-Ching Yuan, Frank Un, Shuya Hu, Chih-Ming Chou, Chun-Han Chen, Jun Wu, Yan Wang, Xiyong Liu, D. Lynne Smith, Hongzhi Li, Zheng Liu, Charles D. Warden, Leila Su, Linda H. Malkas, Young Min Chung, Mickey C.-T. Hu and Yun Yen
Molecular Pharmacology June 1, 2015, 87 (6) 996-1005; DOI: https://doi.org/10.1124/mol.114.094987
Research ArticleArticle
RNR Inhibitor COH29 Interferes with DNA Repair Pathways
Mei-Chuan Chen, Bingsen Zhou, Keqiang Zhang, Yate-Ching Yuan, Frank Un, Shuya Hu, Chih-Ming Chou, Chun-Han Chen, Jun Wu, Yan Wang, Xiyong Liu, D. Lynne Smith, Hongzhi Li, Zheng Liu, Charles D. Warden, Leila Su, Linda H. Malkas, Young Min Chung, Mickey C.-T. Hu and Yun Yen
Molecular Pharmacology June 1, 2015, 87 (6) 996-1005; DOI: https://doi.org/10.1124/mol.114.094987
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