Research ArticleArticle
Lysosomal Sequestration Determines Intracellular Imatinib Levels
Herman Burger, Alexander T. den Dekker, Sandra Segeletz, Antonius W. M. Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H. J. Mathijssen and Erik A. C. Wiemer
Molecular Pharmacology September 2015, 88 (3) 477-487; DOI: https://doi.org/10.1124/mol.114.097451
Herman Burger
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Alexander T. den Dekker
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Sandra Segeletz
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Antonius W. M. Boersma
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Peter de Bruijn
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Maria Debiec-Rychter
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Takahiro Taguchi
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Stefan Sleijfer
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Alex Sparreboom
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Ron H. J. Mathijssen
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
Erik A. C. Wiemer
Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (A.S.)
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Research ArticleArticle
Lysosomal Sequestration of Imatinib
Herman Burger, Alexander T. den Dekker, Sandra Segeletz, Antonius W. M. Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H. J. Mathijssen and Erik A. C. Wiemer
Molecular Pharmacology September 1, 2015, 88 (3) 477-487; DOI: https://doi.org/10.1124/mol.114.097451
Research ArticleArticle
Lysosomal Sequestration of Imatinib
Herman Burger, Alexander T. den Dekker, Sandra Segeletz, Antonius W. M. Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H. J. Mathijssen and Erik A. C. Wiemer
Molecular Pharmacology September 1, 2015, 88 (3) 477-487; DOI: https://doi.org/10.1124/mol.114.097451
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