Rapid CommunicationMinireview—Exploring the biology of GPCRs: from in vitro to in vivo
G Protein–Coupled Receptor Signaling Networks from a Systems Perspective
S. Roth, B. N. Kholodenko, M. J. Smit and F. J. Bruggeman
Molecular Pharmacology September 2015, 88 (3) 604-616; DOI: https://doi.org/10.1124/mol.115.100057
S. Roth
Systems Bioinformatics (S.R., F.J.B.) and Amsterdam Institute for Molecules, Medicines & Systems, VU University, Amsterdam, The Netherlands (M.J.S.); and Systems Biology Ireland, University College Dublin, Dublin, Ireland (B.N.K.)
B. N. Kholodenko
Systems Bioinformatics (S.R., F.J.B.) and Amsterdam Institute for Molecules, Medicines & Systems, VU University, Amsterdam, The Netherlands (M.J.S.); and Systems Biology Ireland, University College Dublin, Dublin, Ireland (B.N.K.)
M. J. Smit
Systems Bioinformatics (S.R., F.J.B.) and Amsterdam Institute for Molecules, Medicines & Systems, VU University, Amsterdam, The Netherlands (M.J.S.); and Systems Biology Ireland, University College Dublin, Dublin, Ireland (B.N.K.)
F. J. Bruggeman
Systems Bioinformatics (S.R., F.J.B.) and Amsterdam Institute for Molecules, Medicines & Systems, VU University, Amsterdam, The Netherlands (M.J.S.); and Systems Biology Ireland, University College Dublin, Dublin, Ireland (B.N.K.)
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In this issue
Rapid CommunicationMinireview—Exploring the biology of GPCRs: from in vitro to in vivo
G Protein–Coupled Receptor Networks: A Systems Perspective
S. Roth, B. N. Kholodenko, M. J. Smit and F. J. Bruggeman
Molecular Pharmacology September 1, 2015, 88 (3) 604-616; DOI: https://doi.org/10.1124/mol.115.100057
Rapid CommunicationMinireview—Exploring the biology of GPCRs: from in vitro to in vivo
G Protein–Coupled Receptor Networks: A Systems Perspective
S. Roth, B. N. Kholodenko, M. J. Smit and F. J. Bruggeman
Molecular Pharmacology September 1, 2015, 88 (3) 604-616; DOI: https://doi.org/10.1124/mol.115.100057
Jump to section
- Article
- Visual Overview
- Abstract
- Introduction
- Why G Protein–Coupled Receptors Are So Attractive for Systems Biology
- Quantification of the Membrane Processes
- Receptor Activation and Conformation Selection
- G Protein Activation and Inactivation Cycles
- Signal Transduction Cascades of Biochemical Reaction Cycles: Sensitivity Amplification
- Negative Feedback in Signal Transduction Cascades: Oscillations and Robustness to Drugs
- Positive Feedback in Signal Transduction Cascades: From Gradual to All-or-None Bistable Responses
- Experimental Observations of Bistability and Oscillations Require Single-Cell Approaches
- Fold-Change Detection by Networks Compensates for Stochastic Fluctuations in Protein Levels
- Outlook: Appreciating How a GPCR Plays a Role in the Decision-Making Machinery of a Cell
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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