Abstract
The α-amino alcohols, histidinol and valinol, inhibited protein synthesis in the rabbit reticulocyte cell-free system by interfering with activation of histidine and valine, respectively. The lower rate of translation resulted in an increase in the polyribosome component of such systems. Histidinol promoted an accumulation of tRNAHis associated with ribosomes, and a similar result was found with valinol. The data indicate that deacylated tRNA is bound to ribosomes in a protein-synthesizing system when the acylated form is unavailable.
- Copyright ©, 1973, by Academic Press, Inc.
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