Research ArticleArticle
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance
Jing Li, Ji Jing, Yang Bai, Zhen Li, Roumei Xing, Binhe Tan, Xueyun Ma, Wen-Wei Qiu, Changsheng Du, Bing Du, Fan Yang, Jie Tang, Stefan Siwko, Mingyao Liu, Huaqing Chen and Jian Luo
Molecular Pharmacology May 2017, 91 (5) 464-474; DOI: https://doi.org/10.1124/mol.116.107136
Jing Li
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Ji Jing
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Yang Bai
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Zhen Li
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Roumei Xing
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Binhe Tan
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Xueyun Ma
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Wen-Wei Qiu
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Changsheng Du
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Bing Du
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Fan Yang
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Jie Tang
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Stefan Siwko
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Mingyao Liu
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Huaqing Chen
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
Jian Luo
Shanghai Fengxian District Central Hospital, Shanghai, People’s Republic of China (J.Li); Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, People’s Republic of China (J.J., Y.B., Z.L., R.X., B.T., X.M., B.D., M.L., H.C., J.Luo); Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of China (W.-W.Q., F.Y., J.T.); Laboratory of Receptor-Based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China (C.D.); Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (S.S., M.L.)
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Research ArticleArticle
SH479 Ameliorates Experimental Autoimmune Encephalomyelitis
Jing Li, Ji Jing, Yang Bai, Zhen Li, Roumei Xing, Binhe Tan, Xueyun Ma, Wen-Wei Qiu, Changsheng Du, Bing Du, Fan Yang, Jie Tang, Stefan Siwko, Mingyao Liu, Huaqing Chen and Jian Luo
Molecular Pharmacology May 1, 2017, 91 (5) 464-474; DOI: https://doi.org/10.1124/mol.116.107136
Research ArticleArticle
SH479 Ameliorates Experimental Autoimmune Encephalomyelitis
Jing Li, Ji Jing, Yang Bai, Zhen Li, Roumei Xing, Binhe Tan, Xueyun Ma, Wen-Wei Qiu, Changsheng Du, Bing Du, Fan Yang, Jie Tang, Stefan Siwko, Mingyao Liu, Huaqing Chen and Jian Luo
Molecular Pharmacology May 1, 2017, 91 (5) 464-474; DOI: https://doi.org/10.1124/mol.116.107136
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