Research ArticleArticle
Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53
Xin Yu, Adam Blanden, Ashley T. Tsang, Saif Zaman, Yue Liu, John Gilleran, Anthony F. Bencivenga, S. David Kimball, Stewart N. Loh and Darren R. Carpizo
Molecular Pharmacology June 2017, 91 (6) 567-575; DOI: https://doi.org/10.1124/mol.116.107409
Xin Yu
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Adam Blanden
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Ashley T. Tsang
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Saif Zaman
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Yue Liu
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
John Gilleran
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Anthony F. Bencivenga
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
S. David Kimball
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Stewart N. Loh
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
Darren R. Carpizo
Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke’s Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)
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Research ArticleArticle
TSCs Reactivate Mutant p53 as Zn Metallochaperones
Xin Yu, Adam Blanden, Ashley T. Tsang, Saif Zaman, Yue Liu, John Gilleran, Anthony F. Bencivenga, S. David Kimball, Stewart N. Loh and Darren R. Carpizo
Molecular Pharmacology June 1, 2017, 91 (6) 567-575; DOI: https://doi.org/10.1124/mol.116.107409
Research ArticleArticle
TSCs Reactivate Mutant p53 as Zn Metallochaperones
Xin Yu, Adam Blanden, Ashley T. Tsang, Saif Zaman, Yue Liu, John Gilleran, Anthony F. Bencivenga, S. David Kimball, Stewart N. Loh and Darren R. Carpizo
Molecular Pharmacology June 1, 2017, 91 (6) 567-575; DOI: https://doi.org/10.1124/mol.116.107409
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