Abstract
Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and β-catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.
Footnotes
- Received December 2, 2016.
- Accepted January 18, 2017.
J.-R.H. and G.-M.T. contributed equally to this work.
This work was supported by the National Natural Science Foundation of China [Grants 31271444, 81201726, and, 8161101021], the Guangdong Natural Science Funds for Distinguished Young Scholar [Grant 2014A030306001], the Guangdong Special Support Program for Young Talent [Grant 2015TQ01R350], the Science and Technology Program of Guangdong [Grant 2016A050502027], and the Foundation for Research Cultivation and Innovation of Jinan University [Grant 21616119]. No potential conflicts of interest were disclosed.
- Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|