Research ArticleMolecular Pharmacology in China
Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism
Shaolan Wang, Xinya Xie, Ting Lei, Kang Zhang, Baochang Lai, Zihui Zhang, Youfei Guan, Guangmei Mao, Lei Xiao and Nanping Wang
Molecular Pharmacology September 2017, 92 (3) 256-264; DOI: https://doi.org/10.1124/mol.116.108100
Shaolan Wang
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Xinya Xie
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Ting Lei
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Kang Zhang
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Baochang Lai
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Zihui Zhang
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Youfei Guan
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Guangmei Mao
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Lei Xiao
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
Nanping Wang
Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University, Xi’an , People’s Republic of China (S.W., X.X., T.L., K.Z., B.L., Z.Z., L.X., N.W.); The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China (Y.G., N.W.); and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (G.M.)
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In this issue
Research ArticleMolecular Pharmacology in China
NLRP3 Inflammasome Inhibition via PXR in Endothelial Cells
Shaolan Wang, Xinya Xie, Ting Lei, Kang Zhang, Baochang Lai, Zihui Zhang, Youfei Guan, Guangmei Mao, Lei Xiao and Nanping Wang
Molecular Pharmacology September 1, 2017, 92 (3) 256-264; DOI: https://doi.org/10.1124/mol.116.108100
Research ArticleMolecular Pharmacology in China
NLRP3 Inflammasome Inhibition via PXR in Endothelial Cells
Shaolan Wang, Xinya Xie, Ting Lei, Kang Zhang, Baochang Lai, Zihui Zhang, Youfei Guan, Guangmei Mao, Lei Xiao and Nanping Wang
Molecular Pharmacology September 1, 2017, 92 (3) 256-264; DOI: https://doi.org/10.1124/mol.116.108100
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