Research ArticleMolecular Pharmacology in China
Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression
Yanhua Wang, Lirong Jiang, Xi Mo, Yu Lan, Xiao Yang, Xinyi Liu, Jian Zhang, Li Zhu, Junling Liu and Xiaolin Wu
Molecular Pharmacology September 2017, 92 (3) 285-296; DOI: https://doi.org/10.1124/mol.116.107417
Yanhua Wang
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Lirong Jiang
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Xi Mo
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Yu Lan
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Xiao Yang
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Xinyi Liu
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Jian Zhang
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Li Zhu
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Junling Liu
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
Xiaolin Wu
Department of Laboratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People’s Republic of China (Y.W.); Institute for Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai, People’s Republic of China (L.J., X.M.); State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, People’s Republic of China (Y.L., X.Y.); Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (X.L., J.Z.); Cyrus Tang Hematology Center, Soochow University, Suzhou, People’s Republic of China (L.Z.); Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China (J.L.); and The Central Laboratory of The Eighth People’s Hospital of Shanghai, Shanghai, People’s Republic of China (X.W.)
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Research ArticleMolecular Pharmacology in China
Lack of Smad4 Affects Platelet Function
Yanhua Wang, Lirong Jiang, Xi Mo, Yu Lan, Xiao Yang, Xinyi Liu, Jian Zhang, Li Zhu, Junling Liu and Xiaolin Wu
Molecular Pharmacology September 1, 2017, 92 (3) 285-296; DOI: https://doi.org/10.1124/mol.116.107417
Research ArticleMolecular Pharmacology in China
Lack of Smad4 Affects Platelet Function
Yanhua Wang, Lirong Jiang, Xi Mo, Yu Lan, Xiao Yang, Xinyi Liu, Jian Zhang, Li Zhu, Junling Liu and Xiaolin Wu
Molecular Pharmacology September 1, 2017, 92 (3) 285-296; DOI: https://doi.org/10.1124/mol.116.107417
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement