Research ArticleArticle
Open Access
NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy
Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Ksenya Varakina, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Sandner, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Doris Koesling, Marlies Knipper and Lukas Rüttiger
Molecular Pharmacology October 2017, 92 (4) 375-388; DOI: https://doi.org/10.1124/mol.117.108548
Dorit Möhrle
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Katrin Reimann
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Steffen Wolter
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Markus Wolters
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Ksenya Varakina
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Evanthia Mergia
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Nicole Eichert
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Hyun-Soon Geisler
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Peter Sandner
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Peter Ruth
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Andreas Friebe
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Robert Feil
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Ulrike Zimmermann
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Doris Koesling
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Marlies Knipper
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
Lukas Rüttiger
Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Tübingen (D.M., K.R., S.W., K.V., N.E., H.-S.G., U.Z., M.K., L.R.), Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen (M.W., R.F.), Department of Pharmacology and Toxicology, University of Bochum, Bochum (E.M., D.K.), Bayer AG, Drug Discovery Pharma Research Centre Wuppertal, Wuppertal (P.S.), Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen (P.R.), and Department of Physiology, University of Würzburg, Würzburg (A.F.), Germany
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Research ArticleArticle
NO-GC Isoforms Contribute to Inner Hair Cell Synaptopathy
Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Ksenya Varakina, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Sandner, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Doris Koesling, Marlies Knipper and Lukas Rüttiger
Molecular Pharmacology October 1, 2017, 92 (4) 375-388; DOI: https://doi.org/10.1124/mol.117.108548
Research ArticleArticle
NO-GC Isoforms Contribute to Inner Hair Cell Synaptopathy
Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Ksenya Varakina, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Sandner, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Doris Koesling, Marlies Knipper and Lukas Rüttiger
Molecular Pharmacology October 1, 2017, 92 (4) 375-388; DOI: https://doi.org/10.1124/mol.117.108548
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