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Moving Synergistically Acting Drug Combinations to the Clinic by Comparing Sequential versus Simultaneous Drug Administrations
Saketh S. Dinavahi, Mohammad A. Noory, Raghavendra Gowda, Joseph J. Drabick, Arthur Berg, Rogerio I. Neves and Gavin P. Robertson
Molecular Pharmacology March 2018, 93 (3) 190-196; DOI: https://doi.org/10.1124/mol.117.110759
Saketh S. Dinavahi
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Mohammad A. Noory
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Raghavendra Gowda
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Joseph J. Drabick
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Arthur Berg
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Rogerio I. Neves
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Gavin P. Robertson
Division of Hematology-Oncology (J.J.D.); Departments of Pharmacology (S.S.D., M.A.N., R.G., R.I.N., G.P.R.), Medicine (J.J.D.), Public Health Sciences (A.B.), Dermatology (R.I.N., G.P.R.), Surgery (R.I.N., G.P.R.), and Pathology (G.P.R.); Melanoma and Skin Cancer Center (S.S.D., M.A.N., R.G., J.J.D., A.B., R.I.N., G.P.R.); Foreman Foundation for Melanoma Research (R.G., G.P.R.); and the Melanoma Therapeutics Program (R.G., R.I.N., G.P.R.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
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Rapid CommunicationAccelerated Communication
Effective AKT and WEE1 Targeting in Melanoma
Saketh S. Dinavahi, Mohammad A. Noory, Raghavendra Gowda, Joseph J. Drabick, Arthur Berg, Rogerio I. Neves and Gavin P. Robertson
Molecular Pharmacology March 1, 2018, 93 (3) 190-196; DOI: https://doi.org/10.1124/mol.117.110759
Rapid CommunicationAccelerated Communication
Effective AKT and WEE1 Targeting in Melanoma
Saketh S. Dinavahi, Mohammad A. Noory, Raghavendra Gowda, Joseph J. Drabick, Arthur Berg, Rogerio I. Neves and Gavin P. Robertson
Molecular Pharmacology March 1, 2018, 93 (3) 190-196; DOI: https://doi.org/10.1124/mol.117.110759
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