Research ArticleArticle
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors
Emma T. van der Westhuizen, Arthur Spathis, Elham Khajehali, Manuela Jörg, Shailesh N. Mistry, Ben Capuano, Andrew B. Tobin, Patrick M. Sexton, Peter J. Scammells, Celine Valant and Arthur Christopoulos
Molecular Pharmacology July 2018, 94 (1) 770-783; DOI: https://doi.org/10.1124/mol.118.111633
Emma T. van der Westhuizen
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Arthur Spathis
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Elham Khajehali
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Manuela Jörg
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Shailesh N. Mistry
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Ben Capuano
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Andrew B. Tobin
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Patrick M. Sexton
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Peter J. Scammells
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Celine Valant
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
Arthur Christopoulos
Drug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.)
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Research ArticleArticle
Characterization of Novel M1 mAChR Allosteric Modulators
Emma T. van der Westhuizen, Arthur Spathis, Elham Khajehali, Manuela Jörg, Shailesh N. Mistry, Ben Capuano, Andrew B. Tobin, Patrick M. Sexton, Peter J. Scammells, Celine Valant and Arthur Christopoulos
Molecular Pharmacology July 1, 2018, 94 (1) 770-783; DOI: https://doi.org/10.1124/mol.118.111633
Research ArticleArticle
Characterization of Novel M1 mAChR Allosteric Modulators
Emma T. van der Westhuizen, Arthur Spathis, Elham Khajehali, Manuela Jörg, Shailesh N. Mistry, Ben Capuano, Andrew B. Tobin, Patrick M. Sexton, Peter J. Scammells, Celine Valant and Arthur Christopoulos
Molecular Pharmacology July 1, 2018, 94 (1) 770-783; DOI: https://doi.org/10.1124/mol.118.111633
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