Fig. 4. Effects of propofol on Ri and half-activation in RVLM neurons. (A) The comparison of Ih amplitude at −120 mV under control conditions and after ZD-7288 (50 μM) and propofol (5, 10, 20 μM) administration. (B) Propofol (0, 5, 10, 20, 40 μM) concentration dependently inhibited Ih in the RVLM presympathetic neurons. (C) Box-and-whisker plots of the effects of ZD-7288 (50 μM), propofol (20 μM), and propofol (20 μM) after ZD-7288 pretreatment (50 μM, 5 minutes) on the Ri of RVLM neurons. (D) Box-and-whisker plot of the effects of propofol (0, 5, 10, 20 μM) on the △V1/2 of Ih in RVLM neurons. PPF, propofol. Values are presented as the mean ± S.D. *P < 0.05; ***P < 0.001, one-way ANOVA with Bonferroni post hoc t test. ns, no significance. n = 7 in each group.