Research ArticleArticle
An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19
Vincent S. Shaw, Mohammadjavad Mohammadi, Josiah A. Quinn, Harish Vashisth and Richard R. Neubig
Molecular Pharmacology December 2019, 96 (6) 683-691; DOI: https://doi.org/10.1124/mol.119.117176
Vincent S. Shaw
Department of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.)
Mohammadjavad Mohammadi
Department of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.)
Josiah A. Quinn
Department of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.)
Harish Vashisth
Department of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.)
Richard R. Neubig
Department of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.)
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Research ArticleArticle
Salt Bridge Drives RGS Flexibility and Inhibitor Selectivity
Vincent S. Shaw, Mohammadjavad Mohammadi, Josiah A. Quinn, Harish Vashisth and Richard R. Neubig
Molecular Pharmacology December 1, 2019, 96 (6) 683-691; DOI: https://doi.org/10.1124/mol.119.117176
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