The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

Jianhong Yang; Wei Yan; Yong Li; Lu Niu; Haoyu Ye; Lijuan Chen

doi:10.1124/mol.119.117812

Research ArticleArticle

The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

Jianhong Yang, Wei Yan, Yong Li, Lu Niu, Haoyu Ye and Lijuan Chen

Molecular Pharmacology December 2019, 96 (6) 711-719; DOI: https://doi.org/10.1124/mol.119.117812

Jianhong Yang

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Wei Yan

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Yong Li

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Lu Niu

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Haoyu Ye

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Lijuan Chen

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu, People’s Republic of China

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Molecular Pharmacology

Vol. 96, Issue 6

1 Dec 2019

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