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Data Supplement
Files in this Data Supplement:
- Data Supplement - Figure 1. Structure of agonists and antagonists used.
- Data Supplement - Figure 2. Amino-acid sequence aligment of TRPV2 orthologues: hTRPV2 (accession number NP_057197), mTRPV2 (accession number NP_035836) and rTRPV2 (accession number NP_058903) proteins were aligned using multiple sequence aligment module of Dnastar software (Lasergen). Aligment was computed using clustall analysis methods with a PAM250 matrix. Grey shaded residues are indicate conservation among the three species, boxes indicated a partial amino acid conservation (two out of three). Horizontal lines indicate transmembrane domains and the square box shows the pore forming regions including the positions of the three mutated amino acids (black dots). Chimera junction sites are represented by black triangles.