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Data Supplement
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- Data Supplement - Supplementary Figure 1. Effects of SC560, nimesulide and NS398 on the intracellular accumulation and retention of doxorubicin in HKESC-1 cells. (A) Shows fluorescent microscopic pictures of HKESC-1 cells that were incubated for 6 h in medium containing 1.25 μM doxorubicin alone, or in combination with 20 μM SC560, 10�n μM nimesulide or 10 μM NS398. Magnification: 400��. (B) Shows fluorescent microscopic picture of HKESC-1 cells treated with 1.25 μM doxorubicin for 6 h, followed by 6 h incubation in normal growth medium or medium containing 20μ M SC560, 10 μM nimesulide or 10μ M NS398. Magnification: 400��. These results are representative of three independent experiments.
- Data Supplement - Supplementary Figure 2. Effects of SC560 (20 μM), nimesulide (10 μM) and NS398 (10 μM) on P-gp ATPase activity. Results are expressed as mean��SEM (n=3) of three independent experiments.
- Data Supplement - Supplementary Figure 3. Effects of indomethacin and SC236 on doxorubicin-induced cytotoxicity in TMK1 cells. Cells were treated for 24 h with doxorubicin (0-10 Mμ) alone, or in combination with indomethacin (20μ M) or SC236 (10μ M). Cell viability was then determined by MTT assay. Data are presented as mean��SEM (n=3) of a representative experiment performed in triplicate.