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Data Supplement
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- Data Supplement -
Supplementary Table I. Affinity (pKi) of H4R ligands at the human, pig, and dog H4Rs and selected human H4R mutants.
Supplementary Table II. Potencies (pEC50) of histamine at the H4 receptor variants.
Supplementary Figure I. Sequence alignment of ADRB2 to H4R orthologs.
Supplementary Figure II. Saturation binding of 3Hhistamine at the H4R orthologs.
Supplementary Figure III. Binding of 3Hhistamine to the human H4R expressed in HEK 293T cells in the absence and presence of 10 microM GTP or GTPgammaS.
Supplementary Figure IV. Functional responses of the H4R orthologs to histamine in a Galphaqi5-directed NFAT-luciferase reporter gene assay.
- Data Supplement -
Supplementary Table I. Affinity (pKi) of H4R ligands at the human, pig, and dog H4Rs and selected human H4R mutants.