Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Data Supplement -
Supplemental Table S1: Electrophysiological parameters of the voltage-dependence of steady-state activation and inactivation
curves for wild type and mutant Nav1.7 channels.
Supplemental Table S2: IC50 values for ProTx-II slowing fast-inactivation of WT sodium channel isoforms and mutant hNav1.7 channels.
Supplemental Fig. S1: Sequence alignment of DIS3-S4 linker on sodium channel isoforms.
Supplemental Fig. S2: HWTX-IV did not slow fast-inactivation of wild type (A) and mutant E818C (B) hNav1.7 channels.
Supplemental Fig. S3: Sequence alignment of DIIS3-S4 linkers of eight sodium channel isoforms.
Supplemental Fig. S4: Mutations in DIV S3-S4 linker differentially alter fast-inactivation of hNav1.7 channels expressed in HEK293 cells.
Supplemental Fig. S5: Mutations in DIV S3-S4 linker differentially alter the effect of ProTx-II on fast-inactivation of hNav1.7-F813G/E818C double mutant channels expressed in HEK293 cells.
- Data Supplement -
Supplemental Table S1: Electrophysiological parameters of the voltage-dependence of steady-state activation and inactivation
curves for wild type and mutant Nav1.7 channels.