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Chemistry
Experimental Procedures for mGluR5 PAMs
Standard Experimental Procedures for mGluR5 NAMs
Figure S1: VU0040228 is selective for mGluR5 versus other mGluR subtypes.
Figure S2: VU0092273 selectivity profile.
Figure S3: VU0285683 is selective for mGluR5 versus other mGluR subtypes.
Figure S4: VU0360172 is selective for mGluR5 versus other mGluR subtypes.
Figure S5: Antagonist VU0285683 fully competes with the equilibrium of 3HmethoxyPEPy (Ki = 16.9 �� 1.1).
Figure S6: In vivo pharmacokinetics of VU0360172 was studied in male SD rats after oral administration of 10 mg/kg dose in 20% hydroxypropyl ��-cyclodextrin (BCD)solution.
- Data Supplement -
Chemistry