Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Methods
Supplemental References
Supplemental Figure 1: hPXR LBD 35S methionine-labeled proteins pull down experiments and Immunoblot.
Supplemental Figure 2: MS and MS/MS spectra of Cpd 3 and Cpd3 structure.
Supplemental Figure 3: Cpd 3 concentration levels in liver, small bowel and plasma extracts.
Supplemental Figure 4: PXR knockdown in LS174T cells.
Supplemental Figure 5: Rescue of PXR phenotype in LS174T cells with PXR silent mutants.
Supplemental Figure 6: Ketoconazole and Cpd 3 inhibitory activity of UGT1A1 Twenty microliter UGTGlo reactions were performed using UGT multienzyme substrate and microsomes (0.2 mg/ml) with various concentrations of ketoconazole (KTZ) and Cpd3 (0-100 muM, respectively).
Supplemental Figure 7: Chemiluminescence method of detecting p-ERK and total ERK in LS174T cell lysate.
- Supplemental Figure 8 - MS and MSMS spectra for the internal standard (anthracene 2).
- Supplemental Data -
Supplemental Methods