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Supplemental Data
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Methods for generation of DOR-KOR heteromer antibody
Supplemental Figure 1 - DOR-KOR monoclonal antibody selectively detects an epitope in cells co-expressing DOR-KOR receptors.
Supplemental Figure 2 - Heteromer selectivity of DOR-KOR monoclonal antibody.
Estimation of allosteric constants alpha and xi
Supplementary Table 1 - KA, tau, and allosteric constants alpha and xi calculated by fitting data shown in Figures 4 (A, B and C) and 6B to Equation 2.
Supplementary Figure 3 - Fit of DOR agonist-mediated inhibition of PGE2-stimulated cAMP accumulation data to a mathematical model of allosterism (Equation 2).
Supplemental References
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