Article Figures & Data
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Supplemental Data
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- Supplemental Data -
Supplementary Table 1 - Summary of adenosine A2A receptor constructs used in the study
Supplementary Table 2 - Affinity of 3HNECA at A2A, A2A(1-316) and the active state StaRs (GL0, GL23, GL26, GL31)
Supplementary Table 3 - Affinity of compounds measured using 3HNECA and 3HZM241385 at the A2A(1-316)
Supplementary Table 4 - Potency of compounds in the functional assay as measured at 0.3 ng/mL doxycycline
Supplementary Figure 1 - Responses of istradefylline, caffeine, ZM241385, SCH58261 and XAC at different levels of constitutive activity
Supplementary Figure 2A - Overlay of the co-crystal structures both UK-432097 (PDB code: 3QAK) and NECA (PDB code: 2YDV) showing the surface of the NECA binding site in grey
Supplementary Figure 3 - ZM241385 sterically prevents movement of H2506.52
- PDB
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Data-based docking of istradefylline docked into the adenosine A2A receptor in the active conformation (2YDV)
- Supplemental Data -