Article Figures & Data
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Data Supplement
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- Data Supplement -
Supplemental Figure 1 - Mechanism of action of the siCHECK-2 Vector Reporter System
Supplemental Figure 2 - Rh123 efflux was measured continuously over five minutes and mean fluorescence units per cell...
Supplemental Figure 3 - Chemical structures of protonatable propafenones GPV005...
Supplemental Figure 4 - First order rate constants are plotted as a function of P-gp expression...
Supplemental Figure 5 - Expression levels of wild type P-gp and tyrosine mutations located in helix 11...
Supplemental Figure 6 - Bar graph showing fractional transport rates of Y307F, Y310F and Y307F/Y310F mutants...
Supplemental Table 1 - IC50 values of compounds in wild type and mutants, calculated from concentration response curves by non-linear regression analysis
Supplemental Table 2 - Statistical significance of differences in IC50 values for compounds GPV005, GPV031 and GPV366 in wild type...
- Data Supplement -