Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Data Supplement -
Figure S-1 - Docking of compounds at a pocket region near the CD45 D1 D2 domain interface
Figure S-2 - Specificity counter-assays for different PTPs and different substrates
Figure S-3 - Quantification of wild type and mutant CD45 phosphatase activity
Figure S-4 - Inhibitors alter the conformation of CD45
Figure S-5 - Effect of 211 treatment on Lck phosphorylation in unstimulated cells
Figure S-6 - Histological staining of sections obtained from mouse foot-pad
Table S-1 - Cell viability with 0.5 muM CD45 inhibitor treatment for 24 hours
Table S-2 - Additional 211 selectivity controls
- PDB 1
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The predicted binding mode of compound 211 into the D1-D2 interface of CD45. The crystal structure of CD45 was downloaded from Protein Data Bank (PDB ID 1YGR)
- Data Supplement -