Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Data Supplement -
Supplemental Figure 1 - Overlay of the crystal structure of Drosophila DAT in complex...
Supplemental Figure 2 - Amino acid sequence alignment of hSERT and hNET based on a previously published alignment of LeuT and SLC6 transporters
Supplemental Figure 3 - Expression and cellular distribution of GFP-tagged versions of WT and mutant forms of SERT and NET...
Supplemental Table 1 - Impact of mutations on 3H5HT uptake kinetics and fluoxetine potency
Supplemental Table 2 - Inhibitory potency of fluoxetine and analogues at selected S1 mutants in SERT
Supplemental Table 3 - Impact of mutations of non-conserved residues in the S1 site of SERT on uptake kinetics and inhibitor potency
Supplemental Table 4 - Impact of mutations of non-conserved residues in the S1 site of NET on uptake kinetics and inhibitor potency
Supplemental Table 5 - Binding affinity of fluoxetine and nisoxetine
SUPPLEMENTAL METHODS
- PDB
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Induced-fit docking model of the human serotonin transporter with S-fluoxetine bound (a representative binding mode from SERT-Cluster 1)
- Data Supplement -