Abstract
UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor (P2Y14R), a G protein-coupled receptor (GPCR) targeted by UDP-sugars, and the increasingly diverse set of physiological responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
- The American Society for Pharmacology and Experimental Therapeutics