Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Figure 1 - Representative structures of (A) 7-alkoxycoumarins (B) 7-alkoxy-4-methylcoumarins and (C) 7-alkoxy-4-(trifluoromethyl)coumarins shown with numbering on the coumarin core and C1-C7 side chain
Supplemental Figure 2 - Effect of chain length on the O-dealkylation of (A) 7-alkoxycoumarins, (B) 7-alkoxy-4-methylcoumarins, and (C) 7-alkoxy-4-(trifluoromethyl)coumarins catalyzed by CYP2B35 (black), CYP2B36 (red) and CYP2B37 (blue) derived from at least three independent experiments
Supplemental Figure 3 - An unbiased Fo-Fc map (3-sigma contour) showing well-defined density for 4CPI molecules in the (A) CYP2B35 active site and (B) CYP2B37 active site and across the substrate access channel
Supplemental Table 1 - Steady-state kinetics of O-dealkylation of selected substrates by CYP2B35 and CYP2B37
Supplemental information on synthesis and compound characterization of 7-alkoxy-4-methylcoumarins and 7-alkoxy-4-(trifluoromethyl)coumarins
- Supplemental Data -