Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Figure 1 - Human GABA-rho-1 alignment using the sequence of the crystal structure of human GABA-beta-3 homopentamer (PDB: 4COF)
Supplemental Figure 2 - Human alpha-7 nicotinic (nAChRa7) and 5-HT3A receptors alignment using the reported sequence of the high resolution structure of torpedo nicotinic acetylcholine receptor in open conformation (PDB: 4AQ9)
Supplemental Figure 3 - Distinctive pockets identified by Pocket Finder in ICM
Supplemental Figure 4 - Schematic representation of the human heteromeric GABAA receptor docked independently to DPA and highlighting each binding site
Supplemental Figure 5 - Post-DPA relaxation positively correlates to the current decay rate of GABA-rho-1 receptors
Supplemental Table 1 - Linear correlations between percentage of DPA-mediated inhibition and physiological properties of mutated GABA receptors
- 5HT3A pentamer docked DPA
-
Homomeric 5-HT3A receptor docked with DPA
- GABA rho1 pentamer docked DPA
-
Homomeric GABA-rho-1 receptor docked with DPA
- Heteromeric GABAA pentamer docked DPA
-
Heteromeric GABAA receptor docked with DPA
- Nicotinic alpha 7 pentamer docked DPA
-
Homomeric nicotinic alpha-7 receptor docked with DPA
- Supplemental Data -