Cdk5 and Abl enzyme substrate (Cables) 1 is adaptor protein to link cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulate the activity of Cdks by enhancing their Y15 phosphorylation. The emerging evidences also show Cables1 can interact with p53 family proteins, 14-3-3, β-catenin and so on, suggesting Cables1 may be a signaling hub to regulate cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other disease. In this review, we summarize the characteristics of Cables1, and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other disease. Finally, we discuss the future challenges to demonstrate the role and potential application of Cables1 in cancer and other disease.
- The American Society for Pharmacology and Experimental Therapeutics