Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Arrestin recruitment to hGPR40
Supplemental Figure 2 - A., B. and C. Bioluminescence resonance energy transfer (BRET)-based biosensor assays were used to directly monitor G protein activation following GPR40 agonist treatment
Supplemental Figure 3 - A. and B. Bioluminescence resonance energy transfer (BRET)-based biosensor assays were used to directly monitor G protein activation following GPR40 agonist treatment in presence or absence of PTX
Supplemental Figure 4 - A. Competition binding experiment using 50 nM [3H]-Compound A. Both
AM-1638 and Compound A completely displaced [3H]-Compound A bindingSupplemental Table 1 - A one-site competition binding model was used to fit the data from Supplemental Figure 4.
Supplemental Methods - Synthesis of Compound A
- Supplemental Data -