Data Supplement

• Supplemental Data -

  Supplemental Table 1 - Histopathology scoring system
  

  Supplemental Table 2-  Retention time, selected reaction monitoring (SRM) and internal standard information used to quantify analytes from arachidonic acid cascade
  

  Supplemental Table 3 - Raw data for figures (units described in respective figure legends)
  

  Supplemental Table 4 - Hepatic oxylipin levels for analytes in the arachidonic acid cascade
  

  Supplemental Figure 1 - Arachidonic acid is metabolized by three major classes of enzymes to produce bioactive oxylipids, including the EETs, which are further metabolized by sEH
  

  Supplemental Figure 2 - All mice gained weight throughout the course of the experiment
  

  Supplemental Figure 3 - Celecoxib and CCl4 modulate metabolites in the P450 branch of the arachidonic acid cascade