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Research ArticleMinireview

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf and Carmen Gallego
Molecular Pharmacology April 30, 2019, mol.118.115329; DOI: https://doi.org/10.1124/mol.118.115329
Joyce Koenen
UMRS996
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Francoise Bachelerie
UMRS996
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Karl Balabanian
UMRS996
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Geraldine Schlecht-Louf
UMRS996
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Carmen Gallego
UMRS996
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Abstract

Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biological processes particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signalling properties together with a new array of other non-chemokine ligands have established ACKR3 as a main regulator of physiological processes at steady state and during inflammation. Here, we present a comprehensive review of ACKR3 expression in mammalian tissues in search of a possible connection with the receptor function. Besides the reported roles of ACKR3 during development, we also discuss the potential contribution of ACKR3 to the function of the immune system, focusing on the myeloid lineage.

  • Cancer
  • Cell differentiation
  • Cell trafficking
  • Chemokine receptors
  • Inflammation
  • Leukocytes
  • Signal transduction networks
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 97 (1)
Molecular Pharmacology
Vol. 97, Issue 1
1 Jan 2020
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Research ArticleMinireview

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf and Carmen Gallego
Molecular Pharmacology April 30, 2019, mol.118.115329; DOI: https://doi.org/10.1124/mol.118.115329

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Research ArticleMinireview

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf and Carmen Gallego
Molecular Pharmacology April 30, 2019, mol.118.115329; DOI: https://doi.org/10.1124/mol.118.115329
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