Abstract

Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biological processes particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signalling properties together with a new array of other non-chemokine ligands have established ACKR3 as a main regulator of physiological processes at steady state and during inflammation. Here, we present a comprehensive review of ACKR3 expression in mammalian tissues in search of a possible connection with the receptor function. Besides the reported roles of ACKR3 during development, we also discuss the potential contribution of ACKR3 to the function of the immune system, focusing on the myeloid lineage.