Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Association and dissociation kinetics of [3H]methoxy-PEPy binding in
HEK293A-mGlu5-low cell membranes.
Supplementary Figure 2 - Correlation plots of affinity, association rate, and dissociation rate of mGlu5 NAMs.
Supplementary Figure 3 - Bmax estimates for [3H]mPEPy binding to mGlu5 in membranes from stable and transient transfected HEK293A cells.
Supplementary Figure 4 - High concentrations of select mGlu5 NAMs interfere with FRET-based assay detection.
Supplementary Figure 5 - Real-time mGlu5 internalization in response to 11.6 µM of L glutamate is inhibited by mGlu5 NAMs.
Supplementary Table 1 - L-glutamate potency for mGlu5 in four functional assays.
Supplementary Table 2 - Potency (pIC50) values from functional assays for mGlu5 NAMs, based on titrations in the presence of sub-maximal L-glutamate.
- Supplemental Data -