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The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
Ian G. Cowell, Elise M. Ling, Rebecca L. Swan, Matilda L.W. Brooks and Caroline A. Austin

Molecular Pharmacology November 2019, 96 (5) 562-572; DOI: https://doi.org/10.1124/mol.119.117390
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Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?
Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan

Molecular Pharmacology November 2019, 96 (5) 527-541; DOI: https://doi.org/10.1124/mol.118.115113
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A Biased View of μ-Opioid Receptors?
Alexandra E. Conibear and Eamonn Kelly

Molecular Pharmacology November 2019, 96 (5) 542-549; DOI: https://doi.org/10.1124/mol.119.115956
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ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel
Yu-Sheng Wu, Janet Jiang, Saumel Ahmadi, Alexandria Lew, Onofrio Laselva, Sunny Xia, Claire Bartlett, Wan Ip, Leigh Wellhauser, Hong Ouyang, Tanja Gonska, Theo J. Moraes and Christine E. Bear

Molecular Pharmacology October 2019, 96 (4) 515-525; DOI: https://doi.org/10.1124/mol.119.117143
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Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation
Seksiri Arttamangkul, Emily R. Leff, Omar Koita, William T. Birdsong and John T. Williams

Molecular Pharmacology October 2019, 96 (4) 505-514; DOI: https://doi.org/10.1124/mol.119.117358
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Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2
Xiao Shi, Tracy L. Swanson, Nicholas B. Miner, Amy J. Eshleman and Aaron Janowsky

Molecular Pharmacology October 2019, 96 (4) 493-504; DOI: https://doi.org/10.1124/mol.119.116798
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Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain
Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein

Molecular Pharmacology October 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947
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Structural Basis for Diltiazem Block of a Voltage-Gated Ca²⁺ Channel
Lin Tang, Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng and William A. Catterall

Molecular Pharmacology October 2019, 96 (4) 485-492; DOI: https://doi.org/10.1124/mol.119.117531
Open Access
Calcium-Sensing Receptor Internalization Is β-Arrestin–Dependent and Modulated by Allosteric Ligands
Iris Mos, Stine E. Jacobsen, Simon R. Foster and Hans Bräuner-Osborne

Molecular Pharmacology October 2019, 96 (4) 463-474; DOI: https://doi.org/10.1124/mol.119.116772
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Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations
Mandeep Atwal, Rebecca L. Swan, Chloe Rowe, Ka C. Lee, David C. Lee, Lyle Armstrong, Ian G. Cowell and Caroline A. Austin

Molecular Pharmacology October 2019, 96 (4) 475-484; DOI: https://doi.org/10.1124/mol.119.117259

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