Abstract
Δ9-Tetrahydrocannabinol was administered to mice intravenously at 15-70 mg/kg. Two hours later the effect of the drug in vivo on brain synaptosomes and spleen lymphocytes was determined. Inhibition of acyl-CoA-lysophosphatidylcholine acyltransferase was significant in the synaptosome (maximum inhibition, 44%) and lymphocyte preparations (maximum inhibition, 24%). In lymphocytes there was concomitant inhibition of blastogenesis as measured by [3H]thymidine incorporation.
ACKNOWLEDGMENT The authors thank Health and Welfare Canada for the gift of cannabinoids.
- Copyright © 1977 by Academic Press, Inc.
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