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Abstract
UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein–coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
Footnotes
- Received February 28, 2015.
- Accepted March 31, 2015.
This work was supported by the National Institutes of Health (NIH) National Institute of General Medical Sciences [Grant R01-GM38213] and the NIH National Heart, Lung, and Blood Institute [Grant P01-HL110873].
- Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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