On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

Data Supplement

Data Supplement

Files in this Data Supplement:

  • Data Supplement - Figure Legends
  • Data Supplement - Fig. 12: Effects of ramatroban, TM30642, TM30643, and TM30089 on PGD2-mediated stimulation of inositolphosphate (IP1) accumulation by CRTH2 in transiently transfected COS7 cells...
  • Data Supplement - Fig. 13: Ramatroban, TM30642, TM30643, and TM30089 lack intrinsic efficacy in various functional assays...
  • Data Supplement - Fig. 14: Inhibition of PGD2-mediated recruitment of barrestin to the CRTH2 receptor by the indicated compounds in HEK293 cells stably transfected with barrestin-GFP2 and CRTH2-Rluc pretreated or not with 50 ng/ml of pertussis toxin (PTX)...
  • Data Supplement - Fig. 15: Effect of TM30642, TM30643, and TM30089 on flow cytometric shape change responses of human eosinophils in response to eotaxin...

This Article

  1. Published online before print January 17, 2006, doi: 10.1124/mol.105.017681
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