Equilibrium constants for NVP-AAM077 acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: implications for studies of synaptic transmission

Data Supplement

Files in this Data Supplement:

• Data Supplement - Supplementary Figure 1. We examined the ability of NVPAAM077 to antagonize NR1/NR2A and NR1/NR2B NMDA receptor-mediated currents evoked by NMDA itself.
  Supplementary Fig. 1A. Concentration-response curves for NMDA at these two receptor subtypes gave estimates...
  Supplementary Fig. 1B. As was the case for glutamate-evoked currents, the IC50 values for NVP-AAM077 acting at NR1/NR2A and NR1/NR2B NMDA receptors differed significantly ...

  Supplementary Figure 2. When compared to the prototypical NMDA receptor antagonist, D-2-amino-5-phosphonopentanoic acid (D-AP5; see Supplementary Fig. 2) our data show that NVP-AAM077 acting at NR1/NR2A NMDA receptors is around...