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This perspective relates to "Ligand-Directed Signaling at the β3-Adrenoceptor Produced by 3-(2-Ethylphenoxy)-1-(1,S)-1,2,3,4-tetrahydronapth-1-ylamino-2S-2-propanol oxalate (SR59230A) Relative to Receptor Agonists by Sato, et al.