Salicylate Alters Expression of Calcium Response Transcription Factor 1 (CaRF1) in the Cochlea: Implications for BDNF Transcriptional Regulation

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  • Data Supplement - Figure 1 Supplement. Immunohistochemistry of phospho-CREB 3h after salicylate treatment (A) The phosphorylation of CREB (red staining) in the nuclei of spiral ganglion neurons is increased 3h after salicylate injection (350 mg/kg). Shown for the apical (upper images), midbasal (images in the middle) and basal (lower images) turns of the cochlea. (B) A higher magnification of phospho-CREB staining (red, arrows) in spiral ganglion neurons is seen in the basal turn of the cochlea. At this magnification level a clear increase can be seen in CREB phosphorylation 3h after 350 mg/kg salicylate injection. The nuclei are counterstained with DAPI. Scale bars in (A) = 50μm, in (B) = 10μm, n = 3.

This Article

  1. Published online before print January 15, 2008, doi: 10.1124/mol.107.041814
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