Targeting MDR1 Gene: Synthesis and Cellular Study of Modified Daunomycin-TFO Conjugates Able to Inhibit Gene Expression in Resistant Cell Lines

Data Supplement

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  Topoisomerase II (topo II) Cleavage Assays.
  Antisense binding.
  Fig. S1. Triplex formation by conjugates PM-DNM and DNM-PM.
  Fig. S2. Cellular uptake of PM-DNM in NIH-MDR-G185 cells.
  Fig. S3. Sequence analysis of topo II-mediated cleavage products in the presence of the TFO-DNM conjugates.
  Fig. S4. Antisense binding analysis.