BCL-2 family inhibitors enhance HDACI+sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing

Data Supplement

Files in this Data Supplement:

• Data Supplement -
  Figure S1. Sorafenib and Vorinostat interact to kill rodent pancreatic tumor cells. ...
  Figure S2. Sorafenib and Vorinostat enhance Grp78/BiP association with CD95 in a FADD-dependent fashion. ...
  Figure S3. Sorafenib and Vorinostat interact to increase PERK and eIF2a phosphorylation and decrease pro-BID levels....
  Figure S4. Expression of dominant negative MEK1 and dominant negative AKT enhances the toxicity of sorafenib+vorinostat exposure...
  Figure S5. Knock out of BAX and BAK abolishes sorafenib and HDACI combination toxicity. ...
• Data Supplement - Complete Figure Legends.