Mol Pharm -- Table of Contents (51 [1])

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January 1997; 51 (1)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Barbara Badio, William L. Padgett, and John W. Daly: Ibogaine: A Potent Noncompetitive Blocker of Ganglionic/Neuronal Nicotinic Receptors
Mol Pharmacol 1997 51: 1-5. [Abstract] [Full Text] [PDF]

Eitan Friedman, Li-Qing Jin, Guo-Ping Cai, Tom R. Hollon, John Drago, David R. Sibley, and Hoau-Yan Wang: D₁-like Dopaminergic Activation of Phosphoinositide Hydrolysis Is Independent of D_1A Dopamine Receptors: Evidence from D_1A Knockout Mice
Mol Pharmacol 1997 51: 6-11. [Abstract] [Full Text] [PDF]

Articles:

Paola Perego, Jennifer Vande Weghe, David W. Ow, and Stephen B. Howell: Role of Determinants of Cadmium Sensitivity in the Tolerance of Schizosaccharomyces pombe to Cisplatin
Mol Pharmacol 1997 51: 12-18. [Abstract] [Full Text] [PDF]

Maurizio Popoli, Alberto Venegoni, Claudia Vocaturo, Liliana Buffa, Jorge Perez, Enrico Smeraldi, and Giorgio Racagni: Long Term Blockade of Serotonin Reuptake Affects Synaptotagmin Phosphorylation in the Hippocampus
Mol Pharmacol 1997 51: 19-26. [Abstract] [Full Text] [PDF]

Rita Musso, Mariagrazia Grilli, Alessandra Oberto, Silvana Ricci Gamalero, and Carola Eva: Regulation of Mouse Neuropeptide Y Y₁ Receptor Gene Transcription: A Potential Role for Nuclear Factor- $kappa$ B/Rel Proteins
Mol Pharmacol 1997 51: 27-35. [Abstract] [Full Text] [PDF]

Jukka Sallinen, Richard E. Link, Antti Haapalinna, Timo Viitamaa, Maya Kulatunga, Birgitta Sjöholm, Ewen Macdonald, Markku Pelto-Huikko, Tiina Leino, Gregory S. Barsh, Brian K. Kobilka, and Mika Scheinin: Genetic Alteration of $alpha$ _2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective $alpha$ ₂-Adrenoceptor Agonist
Mol Pharmacol 1997 51: 36-46. [Abstract] [Full Text] [PDF]

Ivan Yanachkov, Julie Y. Pan, Marianne Wessling-Resnick, and George E. Wright: Synthesis and Effect of Nonhydrolyzable Xanthosine Triphosphate Derivatives on Prenylation of Rab5^D136N
Mol Pharmacol 1997 51: 47-51. [Abstract] [Full Text] [PDF]

Joseph A. Mancini, Philip J. Vickers, Gary P. O'Neill, Catherine Boily, Jean-Pierre Falgueyret, and Denis Riendeau: Altered Sensitivity of Aspirin-Acetylated Prostaglandin G/H Synthase-2 to Inhibition by Nonsteroidal Anti-Inflammatory Drugs
Mol Pharmacol 1997 51: 52-60. [Abstract] [Full Text] [PDF]

Laurent Audoly and Richard M. Breyer: Substitution of Charged Amino Acid Residues in Transmembrane Regions 6 and 7 Affect Ligand Binding and Signal Transduction of the Prostaglandin EP₃ Receptor
Mol Pharmacol 1997 51: 61-68. [Abstract] [Full Text] [PDF]

Xinfang Ma, Dana A. Stoffregen, Geoffrey D. Wheelock, Joseph A. Rininger, and John G. Babish: Discordant Hepatic Expression of the Cell Division Control Enzyme p34^cdc2 Kinase, Proliferating Cell Nuclear Antigen, p53 Tumor Suppressor Protein, and p21^Waf1 Cyclin-Dependent Kinase Inhibitory Protein after WY14,643 ([4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]Acetic Acid) Dosing to Rats
Mol Pharmacol 1997 51: 69-78. [Abstract] [Full Text] [PDF]

Jianhong Luo, Yuehua Wang, Robert P. Yasuda, Anthone W. Dunah, and Barry B. Wolfe: The Majority of N-Methyl-D-Aspartate Receptor Complexes in Adult Rat Cerebral Cortex Contain at Least Three Different Subunits (NR1/NR2A/NR2B)
Mol Pharmacol 1997 51: 79-86. [Abstract] [Full Text] [PDF]

Dana E. Selley, Laura J. Sim, Ruoyo Xiao, Qixu Liu, and Steven R. Childers: µ-Opioid Receptor-Stimulated Guanosine-5 $'$ -O-( $gamma$ -thio)-triphosphate Binding in Rat Thalamus and Cultured Cell Lines: Signal Transduction Mechanisms Underlying Agonist Efficacy
Mol Pharmacol 1997 51: 87-96. [Abstract] [Full Text] [PDF]

Kathleen A. Martin, Sylvia B. Kertesy, and George R. Dubyak: Down-Regulation of P_2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators
Mol Pharmacol 1997 51: 97-108. [Abstract] [Full Text] [PDF]

Miguel Garcia-Guzman, Florentina Soto, Juan Manuel Gomez-Hernandez, Per-Eric Lund, and Walter Stühmer: Characterization of Recombinant Human P2X₄ Receptor Reveals Pharmacological Differences to the Rat Homologue
Mol Pharmacol 1997 51: 109-118. [Abstract] [Full Text] [PDF]

Julie A. Saugstad, J. Mark Kinzie, Michi M. Shinohara, Thomas P. Segerson, and Gary L. Westbrook: Cloning and Expression of Rat Metabotropic Glutamate Receptor 8 Reveals a Distinct Pharmacological Profile
Mol Pharmacol 1997 51: 119-125. [Abstract] [Full Text] [PDF]

Daniel Khananshvili, Brenda Mester, Miriam Saltoun, Xiaolan Wang, Gilat Shaulov, and David Baazov: Inhibition of the Cardiac Sarcolemma Na⁺/Ca²⁺ Exchanger by Conformationally Constrained Small Cyclic Peptides
Mol Pharmacol 1997 51: 126-131. [Abstract] [Full Text] [PDF]

Annalisa Verri, Federico Focher, Giuseppina Priori, Gilles Gosselin, Jean-Louis Imbach, Massimo Capobianco, Anna Garbesi, and Silvio Spadari: Lack of Enantiospecificity of Human 2 $'$ -Deoxycytidine Kinase: Relevance for the Activation of $beta$ -L-Deoxycytidine Analogs as Antineoplastic and Antiviral Agents
Mol Pharmacol 1997 51: 132-138. [Abstract] [Full Text] [PDF]

Maria Michelinaki, Petros Mamos, Charalambos Coutsogeorgopoulos, and Dimitrios L. Kalpaxis: Aminoacyl and Peptidyl Analogs of Chloramphenicol as Slow-Binding Inhibitors of Ribosomal Peptidyltransferase: A New Approach for Evaluating Their Potency
Mol Pharmacol 1997 51: 139-146. [Abstract] [Full Text] [PDF]

F. Peter Guengerich, Alfin D. N. Vaz, Gregory N. Raner, Steven J. Pernecky, and Minor J. Coon: Evidence for a Role of a Perferryl-Oxygen Complex, FeO³⁺, in the N-Oxygenation of Amines by Cytochrome P450 Enzymes
Mol Pharmacol 1997 51: 147-151. [Abstract] [Full Text] [PDF]

P. Y. Law, T. M. McGinn, K. M. Campbell, L. E. Erickson, and H.H. Loh: Agonist Activation of $delta$ -Opioid Receptor but not µ-Opioid Receptor Potentiates Fetal Calf Serum or Tyrosine Kinase Receptor-Mediated Cell Proliferation in a CellLine-Specific Manner
Mol Pharmacol 1997 51: 152-160. [Abstract] [Full Text] [PDF]

Vsevolod V. Gurevich and Jeffrey L. Benovic: Mechanism of Phosphorylation-Recognition by Visual Arrestin and the Transition of Arrestin into a High Affinity Binding State
Mol Pharmacol 1997 51: 161-169. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Stereo view of the proposed interaction between the neuropeptide Y Y₁ receptor and a nonpeptide analog ofthe carboxyl-terminal four amino acids of neuropeptide Y. Thehelices of the human Y₁ receptor are shown in yellow ribbon, andthe side chains of the binding site are shown in yellow. The nonpeptideanalog BIB 3226 is colored by atom type (green, carbon; red, oxygen;blue, nitrogen; white, hydrogen). The model was derived by comparisonof the affinity of neuropeptide Y and BIB 3226 to a large numberof Y₁ receptor mutants expressed in HeLa cells. From Sautel, M.,K. Rudolph, H. Wittneben, H. Herzog, R. Martinez, M. Munoz, W.Eberlein, W. Engel, P. Walker, A. G. Beck-Sickinger. NeuropeptideY and the nonpeptide antagonist BIBP 3226 share an overlappingbinding site at the human Y1 receptor. Mol. Pharmacol. 50:285-292(1996).