Mol Pharm -- Table of Contents (51 [6])

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June 1997; 51 (6)   [Index by Author] [Cover Caption]

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       Accelerated Communication

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Minireview:

Mohanish Deshmukh and Eugene M. Johnson, Jr.: Programmed Cell Death in Neurons: Focus on the Pathway of Nerve Growth Factor Deprivation-Induced Death of Sympathetic Neurons
Mol Pharmacol 1997 51: 897-906. [Abstract] [Full Text] [PDF]

Accelerated Communication:

Jane A. Mitchell, Michael Saunders, Peter J. Barnes, Robert Newton, and Maria G. Belvisi: Sodium Salicylate Inhibits Cyclo-Oxygenase-2 Activity Independently of Transcription Factor (Nuclear Factor $kappa$ B) Activation: Role of Arachidonic Acid
Mol Pharmacol 1997 51: 907-912. [Abstract] [Full Text] [PDF]

Lei Zhang, Mark J. Dresser, Andrew T. Gray, Spencer C. Yost, Shigeyuki Terashita, and Kathleen M. Giacomini: Cloning and Functional Expression of a Human Liver Organic Cation Transporter
Mol Pharmacol 1997 51: 913-921. [Abstract] [Full Text] [PDF]

Articles:

Jian Feng Ma, Geraldine Grant, and Peter W. Melera: Mutations in the Sixth Transmembrane Domain of P-Glycoprotein that Alter the Pattern of Cross-resistance Also Alter Sensitivity to Cyclosporin A Reversal
Mol Pharmacol 1997 51: 922-930. [Abstract] [Full Text] [PDF]

Darryl C. Zeldin, Julie Foley, Susan M. Goldsworthy, Molly E. Cook, James E. Boyle, Jixiang Ma, Cindy R. Moomaw, Kenneth B. Tomer, Charles Steenbergen, and Shu Wu: CYP2J Subfamily Cytochrome P450s in the Gastrointestinal Tract: Expression, Localization, and Potential Functional Significance
Mol Pharmacol 1997 51: 931-943. [Abstract] [Full Text] [PDF]

Dennis R. Koop, Bethany Klopfenstein, Yuji Iimuro, and Ronald G. Thurman: Gadolinium Chloride Blocks Alcohol-Dependent Liver Toxicity in Rats Treated Chronically with Intragastric Alcohol Despite the Induction of CYP2E1
Mol Pharmacol 1997 51: 944-950. [Abstract] [Full Text] [PDF]

Tian-Li Yue, Xinkang Wang, Calvert S. Louden, Shalley Gupta, Kodandaram Pillarisetti, Juan-Li Gu, Timothy K. Hart, Paul G. Lysko, and Giora Z. Feuerstein: 2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression
Mol Pharmacol 1997 51: 951-962. [Abstract] [Full Text] [PDF]

Rebecca Sundseth, Gene Macdonald, Jenny Ting, and A. Christie King: DNA Elements Recognizing NF-Y and Sp1 Regulate the Human Multidrug-Resistance Gene Promoter
Mol Pharmacol 1997 51: 963-971. [Abstract] [Full Text] [PDF]

Zsuzsa Szondy, Uwe Reichert, Jean-Michel Bernardon, Serge Michel, Réka Tóth, Philippe Ancian, Eva Ajzner, and Laszlo Fesus: Induction of Apoptosis by Retinoids and Retinoic Acid Receptor $gamma$ -Selective Compounds in Mouse Thymocytes through a Novel Apoptosis Pathway
Mol Pharmacol 1997 51: 972-982. [Abstract] [Full Text] [PDF]

Carina Shayo, Carlos Davio, Andres Brodsky, Alejandro G. Mladovan, Bibiana Lemos Legnazzi, Elena Rivera, and Alberto Baldi: Histamine Modulates the Expression of c-fos through Cyclic AMP Production via the H₂ Receptor in the Human Promonocytic Cell Line U937
Mol Pharmacol 1997 51: 983-990. [Abstract] [Full Text] [PDF]

Stuart J. Mundell, Jeffrey L. Benovic, and Eamonn Kelly: A Dominant Negative Mutant of the G Protein-Coupled Receptor Kinase 2 Selectively Attenuates Adenosine A₂ Receptor Desensitization
Mol Pharmacol 1997 51: 991-998. [Abstract] [Full Text] [PDF]

Susanne Jacobitz, M. Dominic Ryan, Megan M. McLaughlin, George P. Livi, Walter E. Dewolf, Jr., and Theodore J. Torphy: Role of Conserved Histidines in Catalytic Activity and Inhibitor Binding of Human Recombinant Phosphodiesterase 4A
Mol Pharmacol 1997 51: 999-1006. [Abstract] [Full Text] [PDF]

Hiromichi Fujino, Yoshihisa Kitamura, Takeshi Yada, Takashi Uehara, and Yasuyuki Nomura: Stimulatory Roles of Muscarinic Acetylcholine Receptors on T Cell Antigen Receptor/CD3 Complex-Mediated Interleukin-2 Production in Human Peripheral Blood Lymphocytes
Mol Pharmacol 1997 51: 1007-1014. [Abstract] [Full Text] [PDF]

Nansheng Chen, Ali Moshaver, and Lynn A. Raymond: Differential Sensitivity of Recombinant N-Methyl-D-Aspartate Receptor Subtypes to Zinc Inhibition
Mol Pharmacol 1997 51: 1015-1023. [Abstract] [Full Text] [PDF]

Stefania Scala, Nadia Akhmed, U. S. Rao, Ken Paull, Lu-Bin Lan, Bruce Dickstein, Jong-Seok Lee, Galal H. Elgemeie, Wilfred D. Stein, and Susan E. Bates: P-Glycoprotein Substrates and Antagonists Cluster into Two Distinct Groups
Mol Pharmacol 1997 51: 1024-1033. [Abstract] [Full Text] [PDF]

Douglas W. Loe, Richard K. Stewart, Thomas E. Massey, Roger G. Deeley, and Susan P. C. Cole: ATP-Dependent Transport of Aflatoxin B₁ and Its Glutathione Conjugates by the Product of the Multidrug Resistance Protein (MRP) Gene
Mol Pharmacol 1997 51: 1034-1041. [Abstract] [Full Text] [PDF]

Jean-Luc Morel, Hervé Drobecq, Pierre Sautiere, André Tartar, Jean Mironneau, Janti Qar, Jean-Louis Lavie, and Michel Hugues: Purification of a New Dimeric Protein from Cliona vastifica Sponge, which Specifically Blocks a Non-L-Type Calcium Channel in Mouse Duodenal Myocytes
Mol Pharmacol 1997 51: 1042-1052. [Abstract] [Full Text] [PDF]

Monica Binaschi, Giovanni Capranico, Laura Dal Bo, and Franco Zunino: Relationship between Lethal Effects and Topoisomerase II-Mediated Double-Stranded DNA Breaks Produced by Anthracyclines with Different Sequence Specificity
Mol Pharmacol 1997 51: 1053-1059. [Abstract] [Full Text] [PDF]

Andrea J. Williams, Anton D. Michel, Wasyl Feniuk, and Patrick P. A. Humphrey: Somatostatin₅ Receptor-Mediated [³⁵S]Guanosine-5 $'$ -O-(3-thio)triphosphate Binding: Agonist Potencies and the Influence of Sodium Chloride on Intrinsic Activity
Mol Pharmacol 1997 51: 1060-1069. [Abstract] [Full Text] [PDF]

Annie Michaud, Tracy A. Williams, Marie-Thérèse Chauvet, and Pierre Corvol: Substrate Dependence of Angiotensin I-Converting Enzyme Inhibition: Captopril Displays a Partial Selectivity for Inhibition of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Hydrolysis Compared with That of Angiotensin I^·
Mol Pharmacol 1997 51: 1070-1076. [Abstract] [Full Text] [PDF]

Chung-Chin Kuo, Ren-Shiang Chen, Lu Lu, and Rong-Chi Chen: Carbamazepine Inhibition of Neuronal Na⁺ Currents: Quantitative Distinction from Phenytoin and Possible Therapeutic Implications
Mol Pharmacol 1997 51: 1077-1083. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Stereo view of the proposed interaction between the neuropeptide Y Y₁ receptor and a nonpeptide analog ofthe carboxyl-terminal four amino acids of neuropeptide Y. Thehelices of the human Y₁ receptor are shown in yellow ribbon, andthe side chains of the binding site are shown in yellow. The nonpeptideanalog BIB 3226 is colored by atom type (green, carbon; red, oxygen;blue, nitrogen; white, hydrogen). The model was derived by comparisonof the affinity of neuropeptide Y and BIB 3226 to a large numberof Y₁ receptor mutants expressed in HeLa cells. From Sautel, M.,K. Rudolph, H. Wittneben, H. Herzog, R. Martinez, M. Munoz, W.Eberlein, W. Engel, P. Walker, A. G. Beck-Sickinger. NeuropeptideY and the nonpeptide antagonist BIBP 3226 share an overlappingbinding site at the human Y1 receptor. Mol. Pharmacol. 50:285-292(1996).